https://en.wikipedia.org/wiki/Naked_mole-ratLongevity
Naked mole-rats can live longer than any other rodent, with lifespans in excess of 37 years; the next longest-lived rodent is the African porcupine at 28 years.[38][39][40] The mortality rate of the species does not increase with age, and thus does not conform to that of most mammals (as frequently defined by the Gompertz-Makeham law of mortality).[40] Naked mole-rats are highly resistant to cancer[41]) and maintain healthy vascular function longer in their lifespan than shorter-living rats.[42] Queens age more slowly than nonbreeders.[43]
The mechanisms underlying naked mole-rat longevity are debated, but are thought to be related to their ability to substantially reduce their metabolism in response to adverse conditions, and so prevent aging-induced damage from oxidative stress. This has been referred to as "living their life in pulses".[44] Their longevity has also been attributed to "protein stability".[45] Because of their extraordinary longevity, an international effort was put into place to sequence the genome of the naked mole-rat.[46] A draft genome was made available in 2011[47][48][49] with an improved version released in 2014.[50] Its somatic number is 2n = 60.[7] Further transcriptome sequencing revealed that genes related to mitochondria and oxidation reduction are expressed more than they are in mice, which may contribute to their longevity.[51]
The DNA repair transcriptomes of the liver of humans, naked mole-rats, and mice were compared.[52] The maximum lifespans of humans, naked mole-rats, and mice are respectively c. 120, 30 and 3 years. The longer-lived species, humans and naked mole-rats, expressed DNA repair genes, including core genes in several DNA repair pathways, at a higher level than did mice. In addition, several DNA repair pathways in humans and naked mole-rats were up-regulated compared with mice. These findings suggest that increased DNA repair facilitates greater longevity, and also are consistent with the DNA damage theory of aging.[53]
